I've driven/ridden many section of what's left of Route 66 (and many when it's part of a newer major highway, it's just another interstate freeway). Despite the fact that I usually tease you guys for having a limited selection of interesting roads compared to what we have available in the western US, Route 66 isn't one of those roads to brag about. It was epic when it was the only way to cross the country on one road (FSVO "one road"). There were few sections that could have been interesting on a motorcycle, most are just mostly straight and not-that-interesting to ride through. There are much better ways to get to see the US, not to mention many more interesting roads out west.
After looking at the map TM linked to, I'd much rather do the Scott version than the actual Route 66.