Yep, loss of embouchure will stop brass & woodwind players. I knew a sax player who developed numbness and nerve problems in his lip and couldn't control the reed anymore. He was gutted about it.
The last couple of years I worked playing electric bass I was visited by spells of cramping and charlie horses in my fingers. It had the same effect. It got more frequent until I had to pack it in and retire from regular gigging.